Detalhe da pesquisa
1.
Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling.
Cell
; 184(7): 1884-1894.e14, 2021 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33743210
2.
GPCR-G Protein-ß-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Cell
; 166(4): 907-919, 2016 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27499021
3.
Non-canonical ß-adrenergic activation of ERK at endosomes.
Nature
; 611(7934): 173-179, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36289326
4.
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.
Nature
; 584(7819): 125-129, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32528175
5.
Leveraging nonstructural data to predict structures and affinities of protein-ligand complexes.
Proc Natl Acad Sci U S A
; 118(51)2021 12 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34921117
6.
An allosteric modulator binds to a conformational hub in the ß2 adrenergic receptor.
Nat Chem Biol
; 16(7): 749-755, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32483378
7.
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
Nature
; 535(7610): 182-6, 2016 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27362234
8.
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 15(2): 205, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30504785
9.
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 115(10): E2419-E2428, 2018 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29453275
10.
Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.
Proc Natl Acad Sci U S A
; 115(47): 12046-12050, 2018 11 20.
Artigo
Inglês
| MEDLINE | ID: mdl-30404914
11.
Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 14(11): 1059-1066, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30327561
12.
Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.
J Biol Chem
; 293(46): 17875-17887, 2018 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30237173
13.
Conformational biosensors reveal GPCR signalling from endosomes.
Nature
; 495(7442): 534-8, 2013 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23515162
14.
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Nature
; 485(7398): 321-6, 2012 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22437502
15.
In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes.
J Am Chem Soc
; 139(10): 3607-3610, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28263576
16.
Conformational changes in the G protein Gs induced by the ß2 adrenergic receptor.
Nature
; 477(7366): 611-5, 2011 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-21956331
17.
Crystal structure of the ß2 adrenergic receptor-Gs protein complex.
Nature
; 477(7366): 549-55, 2011 Jul 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21772288
18.
Structure of a nanobody-stabilized active state of the ß(2) adrenoceptor.
Nature
; 469(7329): 175-80, 2011 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21228869
19.
Structure and function of an irreversible agonist-ß(2) adrenoceptor complex.
Nature
; 469(7329): 236-40, 2011 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21228876
20.
The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman.
Mol Pharmacol
; 89(5): 585-92, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26984025